Neural Control of Blood Pressure in Chronic Intermittent Hypoxia
نویسندگان
چکیده
منابع مشابه
Chronic intermittent hypoxia increases blood pressure and expression of FosB/DeltaFosB in central autonomic regions.
Chronic intermittent hypoxia (CIH) models repetitive bouts of arterial hypoxemia that occur in humans suffering from obstructive sleep apnea. CIH has been linked to persistent activation of arterial chemoreceptors and the renin-angiotensin system, which have been linked to chronic elevations of sympathetic nerve activity (SNA) and mean arterial pressure (MAP). Because Fos and FosB are transcrip...
متن کاملChronic intermittent hypoxia increases blood pressure and expression of FosB/ FosB in central autonomic regions
Knight WD, Little JT, Carreno FR, Toney GM, Mifflin SW, Cunningham JT. Chronic intermittent hypoxia increases blood pressure and expression of FosB/ FosB in central autonomic regions. Am J Physiol Regul Integr Comp Physiol 301: R131–R139, 2011. First published May 4, 2011; doi:10.1152/ajpregu.00830.2010.—Chronic intermittent hypoxia (CIH) models repetitive bouts of arterial hypoxemia that occur...
متن کاملA new model of chronic intermittent hypoxia in humans: effect on ventilation, sleep, and blood pressure.
Obstructive sleep apnea is characterized by repetitive nocturnal upper airway obstructions that are associated with sleep disruption and cyclic intermittent hypoxia (CIH) The cyclic oscillations in O(2) saturation are thought to contribute to cardiovascular and other morbidity, but animal and patient studies of the pathogenic link between CIH and these diseases have been complicated by species ...
متن کاملChronic intermittent hypoxia increases sympathetic control of blood pressure: role of neuronal activity in the hypothalamic paraventricular nucleus.
Like humans with sleep apnea, rats exposed to chronic intermittent hypoxia (CIH) experience arterial hypoxemias and develop hypertension characterized by exaggerated sympathetic nerve activity (SNA). To gain insights into the poorly understood mechanisms that initiate sleep apnea/CIH-associated hypertension, experiments were performed in rats exposed to CIH for only 7 days. Compared with sham-t...
متن کاملInvited review: Physiological consequences of intermittent hypoxia: systemic blood pressure.
One of the major manifestations of obstructive sleep apnea is profound and repeated hypoxia during sleep. Acute hypoxia leads to stimulation of the peripheral chemoreceptors, which in turn increases sympathetic outflow, acutely increasing blood pressure. The chronic effect of these repeated episodic or intermittent periods of hypoxia in humans is difficult to study because chronic cardiovascula...
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ژورنال
عنوان ژورنال: Current Hypertension Reports
سال: 2016
ISSN: 1522-6417,1534-3111
DOI: 10.1007/s11906-016-0627-8